Changes in crevicular cytokines after application of melatonin in patients with periodontal disease
Identifieur interne : 000323 ( Main/Exploration ); précédent : 000322; suivant : 000324Changes in crevicular cytokines after application of melatonin in patients with periodontal disease
Auteurs : Javier Montero [Espagne] ; Nansi L Pez-Valverde [Espagne] ; María-José Ferrera [Espagne] ; Antonio L Pez-Valverde [Espagne]Source :
- Journal of Clinical and Experimental Dentistry [ 1989-5488 ] ; 2017.
Abstract
A clinical trial was designed to evaluate the effects of topical application of melatonin on the crevicular fluid levels of interleukins and prostaglandins and to evaluate changes in clinical parameters.
A consecutive sample of 90 patients were recruited from the Health Centre of Pinos Puente in Granada, Spain and divided into 3 groups: 30 patients with diabetes and periodontal disease, who were given melatonin; 30 patients with diabetes and periodontal disease, who were given a placebo, and 30 healthy individuals with no history of systemic disease or clinical signs of periodontal disease, who were also given a placebo. The 30 patients with diabetes and periodontitis were treated with topical application of melatonin (1% orabase cream formula) for 20 days by. The rest of the patients with diabetes and periodontitis and healthy subjects were treated with a placebo of orabase cream. We measured the gingival index by exploring the percentage of standing teeth bleeding on probing. The periodontogram was performed with a Florida Probe.
In the diabetic patients who were given topical melatonin, there was a statistically significant decrease in the two clinical parameters. By contrast, in diabetic patients who were given the topical placebo, there was no statistically significant variation.
In patients with diabetes and periodontal disease, treatment with topical melatonin was associated with a significant improvement in the gingival index and in pocket depth, and a statistically significant reduction in concentrations of interleukin-1β, interleukin-6 and prostaglandin E2 in gingival crevicular fluid.
Url:
DOI: 10.4317/jced.53934
PubMed: 29075409
PubMed Central: 5650209
Affiliations:
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in patients with periodontal disease</title><author><name sortKey="Montero, Javier" sort="Montero, Javier" uniqKey="Montero J" first="Javier" last="Montero">Javier Montero</name><affiliation wicri:level="1"><nlm:aff id="A1">Departament of Surgery, Faculty of Medicine, Scholl of dentistry, University of Salamanca, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Departament of Surgery, Faculty of Medicine, Scholl of dentistry, University of Salamanca</wicri:regionArea><wicri:noRegion>University of Salamanca</wicri:noRegion></affiliation></author><author><name sortKey="L Pez Valverde, Nansi" sort="L Pez Valverde, Nansi" uniqKey="L Pez Valverde N" first="Nansi" last="L Pez-Valverde">Nansi L Pez-Valverde</name><affiliation wicri:level="1"><nlm:aff id="A1">Departament of Surgery, Faculty of Medicine, Scholl of dentistry, University of Salamanca, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Departament of Surgery, Faculty of Medicine, Scholl of dentistry, University of Salamanca</wicri:regionArea><wicri:noRegion>University of Salamanca</wicri:noRegion></affiliation></author><author><name sortKey="Ferrera, Maria Jose" sort="Ferrera, Maria Jose" uniqKey="Ferrera M" first="María-José" last="Ferrera">María-José Ferrera</name><affiliation wicri:level="1"><nlm:aff id="A2">Pinos Puente Health Centre, Granada-Metropolitan Health District, Granada, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Pinos Puente Health Centre, Granada-Metropolitan Health District, Granada</wicri:regionArea><wicri:noRegion>Granada</wicri:noRegion></affiliation></author><author><name sortKey="L Pez Valverde, Antonio" sort="L Pez Valverde, Antonio" uniqKey="L Pez Valverde A" first="Antonio" last="L Pez-Valverde">Antonio L Pez-Valverde</name><affiliation wicri:level="1"><nlm:aff id="A1">Departament of Surgery, Faculty of Medicine, Scholl of dentistry, University of Salamanca, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Departament of Surgery, Faculty of Medicine, Scholl of dentistry, University of Salamanca</wicri:regionArea><wicri:noRegion>University of Salamanca</wicri:noRegion></affiliation></author></analytic><series><title level="j">Journal of Clinical and Experimental Dentistry</title><idno type="eISSN">1989-5488</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>A clinical trial was designed to evaluate the effects of topical application of melatonin on the crevicular fluid levels of interleukins and prostaglandins and to evaluate changes in clinical parameters.</p></sec><sec><title>Material and Methods</title><p>A consecutive sample of 90 patients were recruited from the Health Centre of Pinos Puente in Granada, Spain and divided into 3 groups: 30 patients with diabetes and periodontal disease, who were given melatonin; 30 patients with diabetes and periodontal disease, who were given a placebo, and 30 healthy individuals with no history of systemic disease or clinical signs of periodontal disease, who were also given a placebo. The 30 patients with diabetes and periodontitis were treated with topical application of melatonin (1% orabase cream formula) for 20 days by. The rest of the patients with diabetes and periodontitis and healthy subjects were treated with a placebo of orabase cream. We measured the gingival index by exploring the percentage of standing teeth bleeding on probing. The periodontogram was performed with a Florida Probe.</p></sec><sec><title>Results</title><p>In the diabetic patients who were given topical melatonin, there was a statistically significant decrease in the two clinical parameters. By contrast, in diabetic patients who were given the topical placebo, there was no statistically significant variation.</p></sec><sec><title>Conclusions</title><p>In patients with diabetes and periodontal disease, treatment with topical melatonin was associated with a significant improvement in the gingival index and in pocket depth, and a statistically significant reduction in concentrations of interleukin-1β, interleukin-6 and prostaglandin E2 in gingival crevicular fluid.</p><p><bold> Key words:</bold>Melatonin, periodontal disease, diabetes mellitus, interleukin-1β, interleukin-6, prostaglandin E2.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Ridgeway, Ee" uniqKey="Ridgeway E">EE Ridgeway</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Loesche, Wj" uniqKey="Loesche W">WJ Loesche</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Souza, Ja" 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Diza</name></author><author><name sortKey="Arvanitidou, M" uniqKey="Arvanitidou M">M Arvanitidou</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gamonal, J" uniqKey="Gamonal J">J Gamonal</name></author><author><name sortKey="Acevedo, A" uniqKey="Acevedo A">A Acevedo</name></author><author><name sortKey="Bascones, A" uniqKey="Bascones A">A Bascones</name></author><author><name sortKey="Jorge, O" uniqKey="Jorge O">O Jorge</name></author><author><name sortKey="Silva, A" uniqKey="Silva A">A Silva</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Espagne</li></country></list><tree><country name="Espagne"><noRegion><name sortKey="Montero, Javier" sort="Montero, Javier" uniqKey="Montero J" first="Javier" last="Montero">Javier Montero</name></noRegion><name sortKey="Ferrera, Maria Jose" sort="Ferrera, Maria Jose" uniqKey="Ferrera M" first="María-José" last="Ferrera">María-José Ferrera</name><name sortKey="L Pez Valverde, Antonio" sort="L Pez Valverde, Antonio" uniqKey="L Pez Valverde A" first="Antonio" last="L Pez-Valverde">Antonio L Pez-Valverde</name><name sortKey="L Pez Valverde, Nansi" sort="L Pez Valverde, Nansi" uniqKey="L Pez Valverde N" first="Nansi" last="L Pez-Valverde">Nansi L Pez-Valverde</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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